Category: Histologistics

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Melanin or Melanoma?

Human skin (melanoma?) H&E

Melanoma, a heightened subject that should be talked about with, everyone?  How do you tell the difference between melanin and melanoma?  Research facilities are currently exploring this topic and it’s treatment.  But we do know the primary cause, too much UV rays.  The pathologist can see the difference between melanin and melanoma an H&E stained section, can you?.  Here are some examples.

Human Skin H&E with melanin
Human Skin H&E with melanin
Human skin (I think) stained with H&E
Human skin (I think) stained with H&E 40x

For the rest of us, melanoma is better detected by antibody staining (IHC).  There are a few different antibodies, MART1, Melan, HMB but all I have is Granzyme B.

Human skin Granzyme B 10x Possible melanoma
Human skin Granzyme B 40x Possible melanoma

What do you think?

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Ovarian Carcinoma

In this tissue, it’s diagnosis is ovarian carcinoma.  It’s stained with H&E and pictures taken at multiple areas.  Some (not posted here) look to have melanin deposits but that will have to be discovered using different staining techniques and will update again here.

Enjoy!

Ovarian Carcinoma H&E
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Our Photo’s Have Been Published!

IMG_2777

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

When I first got the calendar from Mercedes Medical in the mail as a promotion, not even looking at it, I tacked it up on the wall.  The first month I saw was March but being so busy, I didn’t even have time to look at the picture.  Then I turned the picture to April and saw the above picture.  Does anyone (beside me) recognize it?  I mean, aside from what stain or tissue it is, but more importantly to me, where it comes from.

I’ll give you a hint, it’s originates from this site.

Aorta- Verhoeff Van Gieson 40x
Aorta- Verhoeff Van Gieson 40x

 

 

 

 

 

 

 

 

 

 

 

 

There are 10 total pictures out of 12 that they bought our pictures from Dreamstime.com.

http://www.dreamstime.com/stock-photo-elastic-tissue-seen-microscope-have-you-ever-human-aorta-stained-to-amplify-s-attributes-most-fibers-image42768709

 

We are now published without recognition and happy about it!  Mercedes will be sending me 5 more calendars free even though I did not tell them about the pictures author, haha.

More of the calendar and pictures can be seen on their website at:

http://www.mercedesmedical.com/default.aspx?Page=customer&file=customer/memesa/customerpages/calendars.htm

Thanks for all you support!

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Hematoxylin & Eosin Staining

microscopic bone marrow stained with H&E

As you can see by our pictures the routine hematoxylin and eosin (H&E) stain is a most popular choice for research, clinical, and vet pathologists.  Before immunohistochemistry (IHC) and immunofluorescence (IF), pathologists would rely solely on routine and special staining for their tissue diagnosis.

Can you diagnosis the correct answer below?