Melanoma, a heightened subject that should be talked about with, everyone?  How do you tell the difference between melanin and melanoma?  Research facilities are currently exploring this topic and it’s treatment.  But we do know the primary cause, too much UV rays.  The pathologist can see the difference between melanin and melanoma an H&E stained section, can you?.  Here are some examples.

Human Skin H&E with melanin

Human Skin H&E with melanin

Human skin (I think) stained with H&E

Human skin (I think) stained with H&E 40x

For the rest of us, melanoma is better detected by antibody staining (IHC).  There are a few different antibodies, MART1, Melan, HMB but all I have is Granzyme B.

Human skin Granzyme B 10x Possible melanoma

Human skin Granzyme B 40x Possible melanoma

What do you think?